If she is going to use them for hunting medium sized game (deer...) the I suggest using the new 110 gr nosler accubond. The bullet should be coming out this summer. Accubonds are very accurate, and extremly effective on shooting medium to large sized game. The lighter the bullet the less recoil will be felt.

As stated before do not go below minimum charge. If she doesn't like the rifle because of the kick then your brother needs to outfit her with a smaller rifle like a 243.