I shot a 140lbs cull buck at 60yds with a federal premium 60gr. hollow point 22-250 and I hit him right in the boiler room(broad side). That guy went 80yds even with a bum foot leaving ZERO blood to track in a heavy fog.
Didnt take long to find but that situation could have gone bad very quickly so im leaving the 22-250 at home for deer from now on.
But they did group well in my Ruger 22-250, if you are dead set on the 22-250 for deer I would use the barnes TSX, those bullets really make the difference in sub calibers.
i would use the .22-250 as a neck gun only...i've killed plenty of animals with it but its iffy with a body shot