I actually use Tite Group and wouldn't be caught dead with Trail Boss in my locker. I have used 5744 for 7.62X39 and cast bullets. It's intriguing why someone wants a reduced .500 load.
Between 1350fps and 2100fps there is no increase in penetration. If you want to better killing/penetrating load then you go up on the bullet weight. Simply trying to make something go faster for the sake of going faster If you're hunting with it is pointless. I have done a bunch of handgun hunting and have never felt that my 357mag, 41mag, 44spl, 44mag, or 45 Colt loads were lacking and never even considered a 500. I do have a few handguns chambered in 454 casull but I don't recall having ever hunted with them.