IMHO, the caliber you shoot has much to do with screws working loose on a rifle.
Well, almost. The amount of recoil more specifically.
My 7 Rem Mag, with a full case of H-Retumbo and a 180 gr is a joy to shoot. Weight of rifle, and a good muzzle brake makes that possible. By contrast, I've shot some .30-06 this year, with a bunch of H-4350 and a 178 gr that were absolutely no fun to shoot.