I'm not real crazy about either after shooting both. We used CCI TNT in my dad's 17hmr on some coons last year up in a tree. We got good hits, good blood, but few instant drops. Some even after being shot two or three times.
I bought a Marlin 22 mag for Christmas (which is a jam-o-matic) and used it to dispatch a skunk I caught in a leg-hold trap under some brush. Again CCI TNT. I think I shot him twice before I got tired of waiting for him to die and just pulled out my 357 and ended it.
If I were to use it on predators, I would be real careful on the placement with either. (unless you just want it to go away and die somewhere else) I just bought a 22 Hornet and I'm hoping for the extra *umphf* to git'er dun!
There's some good research here.
www.varmintal.com